Pacheco left the stadium on crutches and sporting a boot.

Chiefs coach Andy Reid said he was waiting on test results but indicated the injury was significant.

"The only major injury would be Isiah Pacheco," Reid said. "He's having tests on it now -- X-Rays all that stuff."

Pressed on the severity, Reid indicated he was in wait-and-see mode.

"I don't actually know right now. I've just got to see," Reid said. "They're doing all the stuff right now, so I haven't really had a chance to talk to him or anything about it."

Pacheco was injured with just under two minutes remaining, being bent backwards during a tackle by one defender while another had hold of his leg during a 1-yard run. The injury occurred during the Kansas City drive that ended with Harrison Butker's game-ending 51-yard field goal.

Pacheco had 90 yards on 19 carries and caught five passes for 21 yards on Sunday. He has a team-high 135 rushing yards through two games.

Pacheco rushed for 830 yards and five touchdowns as a rookie in 2022. Last season, he rushed for 935 yards and seven scores.

Bears rookie quarterback Caleb Williams threw two interceptions and absorbed seven sacks, with Texans defensive ends Danielle Hunter and Will Anderson Jr. combining for three of those to pace the suffocating attack. Williams passed for 174 yards as the Bears (1-1) totaled just 205 yards of offense.

Texans quarterback C.J. Stroud passed for 260 yards and a touchdown to Nico Collins, who finished with eight catches for 135 yards. Houston extended its lead to 19-10 with 13:39 remaining when Fairbairn drilled a 53-yard field goal after Derek Stingley Jr. picked off Williams.

The third quarter was a slog, with the teams combining for nine penalties and six punts. While the Bears totaled nine penalties for 60 yards for the game, Houston finished with 12 penalties for 115 yards.

Before Chicago settled in defensively, the Texans scored on their first three possessions.

The Texans covered only 33 yards on their first drive but that proved sufficient, as Fairbairn made good on a 56-yard field goal that resulted in a 3-0 lead with 10:20 left in the first quarter.

Stroud and the Texans returned serve, converting a fourth down at midfield before Collins found instant redemption with a 28-yard scoring grab after his 15-yard penalty pushed the Texans out of the red zone. Houston took a 10-3 lead on the first snap of the second quarter and upped the margin to 13-3 when Fairbairn capped an eight-play, 48-yard drive with a 47-yard kick.

The Bears took advantage of a short field and a pass interference penalty on Texans safety Calen Bullock that gave Chicago first-and-goal at the Houston 6-yard line. Khalil Herbert followed with a 2-yard touchdown run that pulled the Bears within 13-10 with 32 seconds left in the first half.

That was just enough time for the Texans to cover 24 yards in five plays, and Fairbairn closed the half with a 59-yarder that pushed Houston to a 16-10 halftime lead.

Patrick Mahomes completed 18 of 25 passes for just 151 yards. He tossed two touchdowns, including a 44-yarder to Rashee Rice, but added two interceptions.

Isiah Pacheco rushed for a team-high 90 yards on 19 carries for the Chiefs (2-0), who outgained the Bengals 149-74 on the ground.

Joe Burrow was 23-of-36 for 258 yards and a pair of touchdown passes to Andrei Iosivas for the Bengals (0-2). The game was another installment of one of the NFL's most riveting rivalries of the last four years. Burrow is 3-2 lifetime against Mahomes.

Saints 44, Cowboys 19

Alvin Kamara scored four touchdowns, including one of Derek Carr's two scoring passes, and New Orleans routed Dallas to end the Cowboys' 16-game home winning streak in the regular season.

Rashid Shaheed caught a 70-yard touchdown from Carr, who finished 11 of 16 for 243 yards with an interception to go along with his two scores. The Saints (2-0) scored touchdowns on their first six possessions to open a 41-19 lead late in the third quarter.

Dak Prescott passed for 293 yards with one touchdown and two interceptions to lead Dallas (1-1). CeeDee Lamb caught a 65-yard touchdown pass and Brandon Aubrey made all four of his field goal attempts.

Chargers 26, Panthers 3

Justin Herbert threw two touchdown passes to Quentin Johnston, J.K. Dobbins rushed for 131 yards and a touchdown and Los Angeles controlled most of the game in a victory against Carolina in Charlotte.

Herbert was just 14-for-20 for 130 yards with an interception, but the Chargers (2-0) didn't need many flashy plays to pick up their first road win under new head coach Jim Harbaugh. Dobbins averaged 7.7 yards on his 17 carries and scored on a 43-yard run that made it 20-0 in the second quarter.

Panthers quarterback Bryce Young generated little offensively. He finished 18-for-26 for 84 yards and an interception. Chuba Hubbard picked up 64 yards on 10 carries. The Panthers (0-2), who lost 47-10 in Week 1 at New Orleans, had only two first downs and 54 yards of total offense by the break.

Raiders 26, Ravens 23

Davante Adams caught nine passes for 110 yards with a touchdown, Daniel Carlson made a 38-yard field goal with 27 seconds left and visiting Las Vegas rallied to beat Baltimore.

Carlson converted a 25-yard field goal before the Raiders (1-1) pulled even at 23 on Adams' 1-yard touchdown catch from Gardner Minshew with 3:54 left to play. The Ravens' next drive stalled, and a poor punt coupled with a penalty situated Las Vegas at the Baltimore 43-yard line with 2:21 to go. Minshew drove the Raiders 23 yards on six plays to set up Carlson's go-ahead kick. Minshew was 30 of 38 for 276 yards with an interception.

Derrick Henry finished with 84 yards and a touchdown on 18 carries, and Lamar Jackson was 21 of 34 for 247 yards with a touchdown and an interception. The Ravens are 0-2 for the first time since 2015.

Packers 16, Colts 10

Malik Willis threw for a touchdown and host Green Bay benefited from a strong rushing attack to beat Indianapolis.

Josh Jacobs had 32 carries for 151 yards and Willis rushed for 41 for the Packers (1-1), who won their 12th straight home opener.

Anthony Richardson completed 17 of 34 passes for 204 yards with a touchdown and three interceptions. Jonathan Taylor, who played collegiately at Wisconsin, rushed for 103 yards on 12 carries and Alec Pierce reeled in a 4-yard touchdown grab for the Colts (0-2).

Buccaneers 20, Lions 16

Baker Mayfield went 12-of-19 passing for 185 yards and a touchdown and added a rushing score to lead visiting Tampa Bay past Detroit.

Chris Godwin caught seven passes for 117 yards and a touchdown for the Buccaneers (2-0), who lost to the Lions in last season's NFC Divisional Playoff in Detroit. Tampa Bay won Sunday despite being outgained 463-216 in total yards.

Aidan Hutchinson had 4.5 sacks for the Lions (1-1), falling one sack short of the franchise record for sacks in a game. Jared Goff went 34-of-55 passing for 307 yards and two interceptions for Detroit.

Vikings 23, 49ers 17

Sam Darnold completed 17 of 26 passes for 268 yards, two touchdowns and one interception, and Minnesota held on to beat San Francisco in Minneapolis.

Justin Jefferson caught four passes for 133 yards, including a career-long 97-yard touchdown, to lead the Vikings (2-0). Jalen Nailor also had a touchdown reception.

Brock Purdy completed 28 of 36 passes for 319 yards, one touchdown and one interception for the 49ers (1-1). Jordan Mason rushed 20 times for 100 yards and a touchdown in his second game in place of injured starter Christian McCaffrey.

Seahawks 23, Patriots 20 (overtime)

Jason Myers nailed a 31-yard field goal with 4:37 remaining in overtime to lift Seattle over New England in Foxborough, Mass.

Myers also came through in the clutch in regulation, putting home a 38-yard field goal that tied the score at 20-all with 55 seconds left. Geno Smith completed 33 of 44 passes for 327 yards and a touchdown for the Seahawks (2-0). His favorite targets were Jaxon Smith-Njigba (12 catches, 117 yards) and DK Metcalf (10 catches, 129 yards, TD).

Running back Antonio Gibson went for 96 yards on the ground for the Patriots (1-1), who got 149 yards and a TD on 15-of-27 passing from Jacoby Brissett.

Jets 24, Titans 17

Braelon Allen scored two touchdowns, including the go-ahead score late in the fourth quarter, as visiting New York rallied in the second half to defeat Tennessee in Nashville, Tenn.

Aaron Rodgers shrugged off a slow start to complete 18 of 30 passes for 176 yards with two touchdowns for the Jets (1-1). Breece Hall added 62 yards on 14 rushes.

Will Levis finished 19-of-28 for 192 yards with a touchdown -- a 40-yard strike to a diving Calvin Ridley with 3:22 left in the third quarter -- and an interception. Ridley scored both Titans (0-2) touchdowns.

Browns 18, Jaguars 13

Deshaun Watson rushed for a touchdown and passed for 186 yards to help Cleveland notch a road victory over Jacksonville.

Dustin Hopkins kicked three field goals and Alex Wright registered a key safety for the Browns (1-1), who converted all three fourth-down opportunities on a muggy afternoon.

Travis Etienne Jr. rushed for a touchdown for the Jaguars (0-2). Trevor Lawrence was 14-of-30 passing for 220 yards for Jacksonville, which has dropped seven of its last eight regular-season contests.

Commanders 21, Giants 18

Austin Seibert kicked a team-record seven field goals, including the game-winner from 30 yards out as time expired, giving Washington the win over New York in Landover, Md.

Commanders rookie Jayden Daniels completed 23 of 29 passes for 226 yards and directed the game-winning drive, which covered 65 yards in the final 2:04. Brian Robinson added a career-high 133 yards on 17 carries as Washington (1-1) snapped an NFL-high nine-game losing streak that dated to last season.

Daniel Jones completed 16 of 28 passes for 178 yards and two touchdowns for the Giants (0-2). Rookie Malik Nabers had 10 receptions for 127 yards and a touchdown, but he dropped a pass on a fourth-down play with 2:04 left, which gave the Commanders their final possession.

Steelers 13, Broncos 6

Justin Fields passed for 117 yards and a score, Darnell Washington caught the game's lone touchdown and visiting Pittsburgh beat Denver.

Chris Boswell kicked two more field goals for the Steelers (2-0), giving him eight in the first two games of the season. Rookie quarterback Bo Nix was 20-for-35 passing for 246 yards and two interceptions in his first home game for the Broncos (0-2).

There was little fanfare for the return of quarterback Russell Wilson to Denver, where he played for two mostly forgettable seasons before signing with the Steelers. Wilson was inactive for the second straight week with a calf injury.

Cardinals 41, Rams 10

Kyler Murray completed 17 of 21 passes for 266 yards and three touchdowns, including two to rookie wideout Marvin Harrison Jr., and Arizona cruised past Los Angeles in Glendale, Ariz.

Harrison finished with four catches for 130 yards for Arizona (1-1), which won its home opener. James Conner had 21 carries for 122 yards and a touchdown. The Cardinals outgained the Rams 489-245.

Matthew Stafford completed 19 of 27 passes for 216 yards for Los Angeles (0-2). Kyren Williams scored the Rams' lone touchdown but was held to 25 yards on 12 carries. Rams wideout Cooper Kupp injured his left ankle in the second quarter and did not return.

Fellow wideout Rome Odunze is set to play in the contest.

Allen didn't practice all week after aggravating a heel injury in last week's season-opening victory over the Tennessee Titans. Odunze sustained a sprained knee against the Titans and returned to practice Friday on a limited basis.

Bears coach Matt Eberflus had said both players were game-time decisions. Allen (908 career receptions) and Odunze (the ninth overall choice of the 2024 draft) are both in their first season with Chicago.

The other inactives for the Bears are offensive lineman Kiran Amegadjie, fullback Khari Blasingame, receiver Velus Jones Jr., defensive lineman Dominique Robinson and linebacker Noah Sewell.

Texans running back Dameon Pierce (hamstring) is inactive. The other Houston inactives are linebackers Jamal Hill and Rashad Weaver, safety M.J. Stewart, receiver John Metchie III and offensive lineman Juice Scruggs.

Kupp was listed as doubtful to return but didn't appear in the second half.

Kupp was injured on his fourth and final reception of the game, a 24-yard gain with 43 seconds left in the first half. He was noticeably limping when he walked off the field at halftime.

Kupp had a stellar start to the season last week when he caught 14 passes for 110 yards and a touchdown in a 26-20 overtime road loss against the Detroit Lions.

The Rams were already without star wideout Puka Nacua, who injured a knee in Week 1 and went on injured reserve.

Patrick Mahomes completed 18 of 25 passes for just 151 yards. He tossed two touchdowns, including a 44-yarder to Rashee Rice, but added two interceptions.

With his team down two, Mahomes received one final chance after rookie safety Daijahn Anthony was called for pass interference with 38 seconds remaining as the Chiefs faced fourth-and-16 from their own 35.

Joe Burrow was 23-of-36 for 258 yards and a pair of touchdown passes to Andrei Iosivas.

The game was another installment of one of the NFL's most riveting rivalries of the last four years. Burrow is 3-2 lifetime against Mahomes.

Burrow started the game completing his first six targets to tight ends for 93 yards, three of which went to Drew Sample and another two to rookie Erick All.

After a 33-yard Evan McPherson field goal made it 13-10 in the second quarter, Cincinnati's Sheldon Rankins punched the ball loose from running back Carson Steele at midfield and Germaine Pratt recovered. The Bengals converted with McPherson's third field goal of the day, a 48-yarder.

Trey Hendrickson, who beat rookie left tackle Kingsley Suamataia for two sacks, provided a key spark to the defense with a sack of Patrick Mahomes on Kansas City's final drive before the half.

The Chiefs drove 70 yards on the opening possession of the second half and took their first lead of the game, 17-16, on a 1-yard tackle-eligible pass to Wanya Morris.

Burrow answered with a long drive of his own, capped with a fourth-down touchdown pass of 4 yards to Iosivas. The extra point was missed and the Bengals led, 22-17.

Cam Taylor-Britt, burned on the 44-yard TD pass to Rice, redeemed himself with a spectacular one-handed grab of a Mahomes pass intended for Xavier Worthy.

Burrow was taken down on a scramble the next time the Bengals had the ball, and cornerback Chamarri Conner scooped up his fumble and ran 38 yards for the go-ahead score and a 23-22 Chiefs lead.

Ja'Marr Chase nearly cost the Bengals dearly on the next drive, as he was hit with a 15-yard unsportsmanlike penalty after being taken to the ground hard by corner Trent McDuffie.

Burrow came over to try and settle him down but not before the flag came out. Still, McPherson connected on his fourth field goal of the day, from 53 yards with 9:28 left in the fourth quarter.

The Bengals lost defensive tackle B.J. Hill to a left hamstring injury midway through the second quarter.

Chris Boswell kicked two more field goals for Pittsburgh (2-0), and now has eight in the first two games.

There was little fanfare for the return of quarterback Russell Wilson to Denver, where he played for two mostly forgettable seasons before signing with the Steelers. Wilson was inactive for the second straight week with a calf injury.

Rookie quarterback Bo Nix was 20-for-35 passing for 246 yards and two interceptions in his first home game for the Broncos (0-2). Will Lutz kicked two field goals for Denver.

Pittsburgh's stingy defense bottled up Nix most of the day and harassed the rookie quarterback into mistakes. The Broncos went three-and-out on their first two possessions and didn't cross the 50-yard line until late in the second quarter.

The Steelers did enough offensively to win their second straight road game to begin the season. On their second possession, Fields engineered a 12-play, 78-yard drive that consumed 7:34 and converted two third downs.

Fields, who was 13-for-20, capped it with a five-yard strike to Washington to make it 7-0 with 1:56 left in the first quarter. It was Pittsburgh's first touchdown of the season.

Boswell added a 22-yard field goal on the last play of the second quarter to give the Steelers a 10-0 halftime lead. His 53-yarder in the third gave Pittsburgh a 13-0 lead.

Denver finally had a sustained drive on its second possession of the third quarter, moving from its own 15 to the Steelers' 6 but Nix's pass intended for Courtland Sutton was intercepted in the end zone by Cory Trice Jr.

The Broncos broke through in the fourth quarter and avoided being shutout at home. Nix hit Josh Reynolds on a fourth-and-six from the Pittsburgh 42 and three plays later Lutz hit a 35-yard field goal.

Lutz made a 29-yard field goal with 1:53 left and Denver had one last chance with 1 second left down 13-6, but Nix's desperation pass was intercepted by Damontae Kazee.

Harrison finished with four catches for 130 yards for Arizona (1-1), which won its home opener. James Conner had 21 carries for 122 yards and a touchdown.

Matthew Stafford completed 19 of 27 passes for 216 yards for Los Angeles (0-2). Kyren Williams scored the Rams' lone touchdown but was held to 25 yards on 12 carries.

Rams wideout Cooper Kupp injured his left ankle in the second quarter and did not return. Kupp, who finished with four catches for 37 yards, limped as he left the field.

The Cardinals outgained the Rams 489-245.

Harrison scored back-to-back touchdowns in the first quarter to give the Cardinals a 14-0 lead. He caught a 23-yard pass for his first career score, and he added an explosive play with a 60-yard touchdown less than three minutes later.

Murray put the Cardinals on top 21-0 early in the third quarter when he connected with Elijah Higgins for an 18-yard touchdown.

A 29-yard field goal by the Rams' Joshua Karty cut the lead to 21-3 on the next drive.

Arizona led 24-3 at halftime after Matt Prater made a 48-yard field goal with 5:09 left.

After the half, Arizona maintained its pressure on the Rams. Conner scored a 5-yard rushing touchdown and Prater made a 57-yard field goal to boost the Cardinals' lead to 34-3 with 3:26 remaining in the third quarter.

Williams gave the Rams their first touchdown on a 4-yard run with 41 seconds to go in the third quarter. It marked his second rushing score in as many games this season.

A fortunate bounce helped the Cardinals increase their advantage to 41-10 with 9:02 left.

Conner rushed left but lost a fumble inside the Rams' 5-yard line. The ball bounced forward across the goal line, where tight end Trey McBride pounced on it for a fumble recovery touchdown.

Arizona linebacker Dennis Gardeck recorded three sacks, as Stafford went down five times in all.

"It's unfortunately looking like that," Jets coach Robert Saleh told reporters. "We'll confirm it tomorrow, but it doesn't look good."

Johnson will undergo an MRI exam to determine the severity.

Johnson said he cried in the locker room and called his mom and other family members after being told he had a serious injury.

"I'm hoping for the best. We still have to clarify and make sure," Johnson told reporters. "It wasn't fun."

Johnson, 25, is in his third season after being a first-round choice (No. 26 overall) in the 2022 NFL Draft.

He recorded 7.5 sacks and made 55 tackles last season while making his first Pro Bowl.

Johnson had two tackles -- one for loss -- before being hurt.

Jets inside linebacker C.J. Mosley (right big toe) was carted off in the second quarter. He had three tackles before departing.

Saleh said he was hopeful Mosley will be available for Thursday night's home game against the New England Patriots.

Bosa appeared to injure his left ankle, which was rolled up on by a teammate as he attempted to rush the pocket. He walked to the sidelines under his own power.

Separately, Jefferson appeared to injure his right leg as he also got rolled up on during the play. Jefferson walked slowly off the field with his arms draped around the Vikings' training staff.

Bosa had two sacks and four tackles at the time of his injury.

Jefferson had four catches for 133 yards and a touchdown. He hauled in a career-long 97-yard touchdown in the first half.

Commanders rookie Jayden Daniels completed 23 of 29 passes for 226 yards and directed the game-winning drive, which covered 65 yards in the final 2:04.

Brian Robinson added a career-high 133 yards on 17 carries as Washington (1-1) snapped an NFL-high nine-game losing streak which dated to last season.

Seibert, who has kicked for four other NFL teams and was signed early last week, made all seven of his field goal tries. The previous Washington record in a game was five field goals, accomplished by five different kickers. The NFL record is eight by Tennessee's Rob Bironas against Houston in 2007.

Daniel Jones, who entered with a 5-1-1 record against Washington, completed 16 of 18 passes for 178 yards and two touchdowns as the Giants fell to 0-2.

Giants rookie Malik Nabers had 10 receptions for 127 yards and a touchdown. But Nabers dropped a pass on a fourth-down play with 2:04 left which gave the Commanders their final possession.

Daniels responded with a 34-yard strike across the middle to Noah Brown. Daniels later set up the game-winning boot with a 14-yard scramble to the Giants' 10.

The Giants trailed 15-12 early in the fourth quarter before Jones directed a 13-play, 70-yard drive, which he capped with a 7-yard touchdown pass to Wan'Dale Robinson on a third-and-goal play that put New York up 18-15 with 11:32 left. The two-point conversion pass failed.

Washington responded by driving to the Giants' 6. But after two false start calls against the Commanders, they opted for a 33-yard field goal by Seibert which tied it 18-all with 7:12 left.

Washington dominated possession throughout, holding the ball for 37:32 compared to 22:28 for New York. But the Commanders committed false start penalties, which forced them to settle for four field goals.

New York was hampered by the loss of veteran kicker Graham Gano, who entered the game on the injured list and was hurt on the opening kickoff. He was helped off the field and didn't return.

Giants punter Jamie Gillan attempted one extra point but it was wide and New York went for two-point conversion attempts after their second and third touchdowns, failing both times.

Devin Singletary rushed 16 times for 95 yards, including a touchdown late in the first half to put the Giants up 12-9 at the break.

Allen snapped a tie with 4:31 left when he roared 20 yards off right tackle to cap a 74-yard drive. Aaron Rodgers hit Mike Williams on second-and-16 for a 19-yard gain to the Tennessee 26 two players before Allen scored the game-winner.

Rodgers shrugged off a slow start to complete 18 of 30 passes for 176 yards with two touchdowns for New York (1-1). Breece Hall added 62 yards on 14 rushes.

The Titans (0-2) had a chance to tie the game in the last minute when Will Levis avoided a sack and scrambled 13 yards to the 10-yard line to set up first-and-goal. But a third-down sack by Will McDonald IV forced a fourth-and-goal play from the 14, and Levis' pass for Tyler Boyd was bobbled around the 3-yard line and fell incomplete.

Levis finished 19-of-28 for 192 yards with a touchdown -- a 40-yard strike to a diving Calvin Ridley with 3:22 left in the third quarter -- and an interception. Ridley scored both Tennessee touchdowns.

Tennessee initiated scoring at the 2:30 mark of the first quarter when Ridley took a reverse 10 yards, capping a 68-yard drive that chewed up more than 6 1/2 minutes.

The Titans crafted another good-looking drive after that but it ended when Levis tried to lateral the ball to Tony Pollard to avoid a sack and instead fumbled to Quincy Williams at the 12, costing them a possible field goal opportunity.

Levis then started the next possession by tossing an interception to Brandin Echols.

The Jets finally got something going after the second turnover, driving 73 yards in 12 plays and scoring with 1:47 left in the half on Rodgers' 12-yard pass to Allen. But Tennessee responded with a 41-yard field goal from Nick Folk as time expired, giving it a 10-7 edge at halftime.

New England (1-1) got the ball to begin the extra session but went three-and-out. The Seahawks capitalized, using eight plays to move 71 yards to Myers' game-winner.

Myers also came through in the clutch in regulation, putting home a 38-yard field goal that tied the game at 20-all with 55 seconds left.

The Patriots went up 20-17 with 12:43 left in the fourth quarter when Rhamondre Stevenson polished off an 11-play, 66-yard march by taking a direct snap and bursting into the end zone from 1 yard out. Stevenson finished with 81 yards and the score on 21 carries.

Seattle (2-0) mustered just one first down on the ensuing possession before punting the ball away. A 45-yard run from Antonio Gibson helped the Patriots work down to the Seahawks 21, but New England ended up having to bring the field-goal unit out.

Joey Slye had his 48-yard field-goal attempt blocked by Julian Love, allowing Seattle to take over at its own 38.

Geno Smith completed 33 of 44 passes for 327 yards and a touchdown for the Seahawks. His favorite targets were Jaxon Smith-Njigba (12 catches, 117 yards) and DK Metcalf (10 catches, 129 yards, TD).

Gibson went for 96 yards on the ground for the Patriots, who got 149 yards and a TD on 15-of-27 passing from quarterback Jacoby Brissett.

Rookie Ja'Lynn Polk capped an eight-play, 60-yard drive with his first career touchdown reception, hauling in a 5-yard pass from Brissett to give New England a 7-0 lead with 4:56 left in the first quarter.

Four plays later, Smith connected with Metcalf for a 56-yard scoring strike that drew the Seahawks even.

Slye booted a 29-yard field goal early in the second quarter, but Seattle went back in front when Zach Charbonnet rushed for a 1-yard TD with 5:47 to go in the frame.

New England pulled within 14-13 when Slye made good on a 28-yard field goal with 2:31 remaining in the first half.

However, Myers drilled a 44-yarder as time expired in the half to provide the Seahawks with a 17-13 advantage at the break.

Justin Jefferson caught four passes for 133 yards, including a career-long 97-yard touchdown, to lead Minnesota (2-0). Jalen Nailor also had a touchdown reception.

Brock Purdy completed 28 of 36 passes for 319 yards, one touchdown and one interception for San Francisco (1-1). Jordan Mason rushed 20 times for 100 yards and a touchdown in his second game in place of injured starter Christian McCaffrey.

Minnesota improved to 2-0 to start the season for the first time since 2016.

Jefferson and 49ers pass rusher Nick Bosa both limped off the field after they were injured on the same play in the third quarter. Bosa returned to the game in the fourth quarter, but Jefferson did not return after his injury.

The Vikings led 3-0 at the end of the first quarter and 13-7 at halftime.

Jefferson put Minnesota on top 10-0 with 9:35 remaining in the second quarter. He got behind the 49ers secondary, caught a deep ball from Darnold in stride, changed direction and streaked toward the right corner of the end zone for a 97-yard score.

The 49ers pulled within 10-7 when Purdy connected with George Kittle for a 7-yard touchdown with 1:53 to go in the half.

Will Reichard drilled a 39-yard field goal as time expired in the half to make it 13-7.

The Vikings provided the only touchdown of the third quarter after Purdy's lone interception set up the home team at the San Francisco 10-yard line.

On the first play of the drive, Darnold maintained the pressure against his former team by hitting Nailor for a 10-yard score to increase Minnesota's lead to 20-7.

The 49ers tried to play catch-up but failed to take the lead in the fourth quarter.

Mason brought San Francisco within 20-14 on a 10-yard touchdown with 10:16 to go, capping a 12-play, 99-yard drive.

Reichard gave the Vikings breathing room with a 27-yard field goal with 3:30 remaining.

Down by two scores, the 49ers settled for a 31-yard field goal by Jake Moody to cut the deficit to 23-17 with 1:12 to play. San Francisco tried an onside kick but did not recover, and Darnold kneeled twice to run out the clock.

Travis Etienne Jr. rushed for a touchdown for the Jaguars (0-2). Trevor Lawrence was 14-of-30 passing for 220 yards for Jacksonville, which has dropped seven of its last eight regular-season contests.

The Jaguars made a late dash after taking over at their own 10-yard line with 1:27 left. On the final play from the Cleveland 33-yard line, Brenton Strange came up empty while making a diving attempt to catch Lawrence's throw to the end zone.

Watson completed 22 of 34 passes just six days after a civil suit was filed accusing him of sexual assault. Watson served an 11-game suspension in 2022 due to two dozen claims of sexual misconduct from women.

Jacksonville tight end Evan Engram (hamstring) missed the game after being injured in pre-game warmups. Cleveland wideout David Bell (hip) was carted off the ball early in the third quarter.

Trailing by 13, Jacksonville showed life late in the third quarter when Lawrence threw deep and connected with rookie Brian Thomas Jr. on a 66-yard -play to the Browns' 6. Two plays later, Etienne scored from the 4 to bring the Jaguars within 16-10 with 1:11 left in the third quarter.

Jacksonville pulled within 16-13 on Cam Little's 25-yard field goal with 7:32 left in the game.

A late-game 39-yard punt by Cory Bojorquez pinned the Jaguars on their own 2-yard line. Lawrence was sacked in the end zone by Wright on the next play to give Cleveland a five-point lead with 1:44 to play.

Cleveland scored points on all three first-half drives and controlled the ball for 20:08 while taking a 13-3 halftime lead.

The Browns put together a 16-yard, 89-yard drive that lasted 9:14 the first time they possessed the ball. Watson capped the drive with a 1-yard scoring run with 2:29 left in the period.

Hopkins added a 38-yard field goal with 27 seconds left.

Less than five minutes later, Little's 43-yard field goal attempt hit the right upright and was no good.

Starting in place of the injured Jordan Love, Willis connected on a 14-yard scoring strike to Dontayvion Wicks to cap an 11-play, 82-yard drive in the first quarter.

Willis completed 12 of 14 passes for just 122 yards. He was making his fourth career NFL start and first with Green Bay after being acquired by the club from the Tennessee Titans on Aug. 26 for a seventh-round pick in the 2025 NFL Draft.

Josh Jacobs had 32 carries for 151 yards and Willis rushed for 41 for the Packers (1-1), who won their 12th straight home opener.

Green Bay held a distinct edge in time of possession (40:11-19:49) and went 10-for-17 on third-down conversion attempts, while Indianapolis was 2-for-9.

Rookie Brayden Narveson kicked field goals of 46, 42 and 34 yards for the Packers.

Indianapolis' Anthony Richardson completed 17 of 34 passes for 204 yards with a touchdown and three interceptions. Jonathan Taylor, who played collegiately at Wisconsin, rushed for 103 yards on 12 carries and Alec Pierce reeled in a 4-yard touchdown grab for the Colts (0-2).

Green Bay ignited its ground game on its initial drive, rushing for 52 yards before Narveson drilled his first field-goal attempt to open the scoring.

The Colts went three-and-out on their ensuing possession before the Packers extended their lead to 10-0 on their next drive. Willis rushed for 12 yards on the 10th play of the drive before finding Wicks, who scooted along the right sideline and into the end zone.

Jacobs nearly gave the Packers a bigger cushion on their next drive before fumbling at the goal line.

Narveson made his second field-goal attempt before Matt Gay answered with a 34-yard kick, trimming the Packers' lead to 13-3 with 4:32 remaining in the third quarter.

Gay was unable to bring Indianapolis closer early in the fourth quarter after he pushed a 50-yard field-goal attempt wide left. Green Bay made the Colts pay after Narveson connected on his third field-goal attempt.

Chris Godwin caught seven passes for 117 yards and a touchdown for the Buccaneers (2-0).

Jared Goff went 34-of-55 passing for 307 yards and two interceptions in defeat for the Lions (1-1).

Aidan Hutchinson had 4.5 sacks for Detroit, falling one sack short of the franchise record for sacks in a game.

Leading by four in the fourth quarter, Tampa Bay stopped the Lions on downs at their 6-yard line with 53 seconds remaining in the game.

But Detroit forced a punt and got the ball back with 33 seconds left at the Tampa Bay 44-yard line.

The Lions drove as far as the Tampa Bay 26 with 14 seconds remaining, but three straight incompletions ended the game.

Tampa Bay prevailed despite Detroit holding a 463-216 edge in total yards.

Trailing 13-9, the Lions took their first lead of the game with 3:26 left in the third quarter on a 1-yard touchdown run by David Montgomery that made it 16-13 Detroit.

The run finished off a 12-play, 68-yard drive that saw the Lions register three third-down conversions.

Tampa Bay answered right back, driving 70 yards in six plays and grabbing a 20-16 lead on an 11-yard touchdown run by Mayfield.

With the game tied at 6-6 in the second quarter, the Buccaneers took the lead with 9:08 until halftime on a 41-yard touchdown pass from Mayfield to Godwin.

Tampa Bay established a 6-0 lead in the first quarter on field goals of 30 and 55 yards by Chase McLaughlin, but Detroit tied the game with field goals of 22 and 35 yards by Jake Bates.

Carr completed 11 of 16 passes for 243 yards and connected with Rashid Shaheed on a 70-yard score, and Kamara had 115 rushing yards and 65 receiving yards as the Saints (2-0) kept rolling after a 47-10 victory against Carolina in their season opener.

Dak Prescott passed for 293 yards with one touchdown and two interceptions to lead the Cowboys (1-1), who were limited to field goals on four of their scoring drives and couldn't keep up with New Orleans' scoring pace.

On the first possession of the third quarter, Dallas drove to Brandon Aubrey's 40-yard field to trim the Saints' lead to 35-19.

Kamara's 7-yard touchdown run produced New Orleans' sixth touchdown in as many possessions, and after the PAT was blocked, the Saints led 41-19 at the end of the third quarter.

Carr's fourth-quarter interception ended a streak of 16 consecutive scoring possessions for the team's starting offense, but Blake Grupe added a 26-yard field goal later in the quarter.

The Saints received the opening kickoff and drove 80 yards, the last 5 of which came on Kamara's touchdown run.

The Cowboys' first possession ended with Aubrey kicking a 52-yard field goal, but on the next play from scrimmage, Carr and Shaheed -- who teamed for a 59-yard touchdown in the opener -- connected for a 14-3 lead that held up through the end of the first quarter.

Aubrey added a 38-yard field goal early in the second quarter, but four plays later Kamara caught a short pass from Carr and turned it into a 57-yard touchdown for a 21-6 lead.

Dallas answered with its only touchdown on a 65-yard pass from Prescott to CeeDee Lamb.

Kamara's 12-yard touchdown run increased the lead to 28-13. Paulson Adebo intercepted Prescott and returned it 47 yards, setting up Carr's 1-yard touchdown run.

Aubrey kicked a 48-yard field goal as time expired, leaving New Orleans with a 35-16 halftime lead.

Herbert was just 14-for-20 for 130 yards with an interception, but the Chargers (2-0) didn't need many flashy plays to pick up their first road win under new head coach Jim Harbaugh.

Dobbins averaged 7.7 yards on his 17 carries and scored on a 43-yard run that made it 20-0 in the second quarter. Johnston finished with five receptions and 51 yards to complement his two scores.

Panthers quarterback Bryce Young generated little offensively. He finished 18-for-26 for 84 yards and an interception. Chuba Hubbard picked up 64 yards on 10 carries.

Los Angeles stifled Carolina to lead 20-0 at halftime. The Panthers (0-2), who lost 47-10 in Week 1 at New Orleans, had only two first downs and 54 yards of total offense by the break.

By then, there were boos from the Carolina crowd directed at the Panthers in their home opener.

Carolina started the second half by scoring on Eddy Pineiro's 38-yard field goal. Cameron Dicker restored the 20-point margin on the next possession with a 46-yard field goal for Los Angeles. Dicker hit a 42-yarder in the fourth quarter to close the scoring.

The Chargers tallied 204 yards of first-half offense to seize control.

Herbert capped a 13-play, 67-yard drive on the game's first possession with a 29-yard touchdown pass to Johnston. The pair connected again on a 5-yard score that made it 13-0 with 4:16 remaining before halftime. Dicker missed the extra point after Johnston's first touchdown.

The Panthers had an early chance at points after Jaycee Horn intercepted Herbert on the first play of Los Angeles' second possession.

Carolina took over at the Chargers' 41-yard line and moved into field goal range before Young was sacked on third down to force a punt. The Panthers failed to record a first down in the opening quarter.

Elijah Molden's interception halted Carolina's possession after Johnston's second score. Dobbins ripped off his 43-yard scamper three plays later to cap the 53-yard drive.

The Ravens are 0-2 for the first time since 2015 after a 27-20 loss to the two-time defending champion Kansas City Chiefs in the NFL opener Sept. 5.

Las Vegas (1-1) was focused on Derrick Henry, who barreled through the defensive line for a 29-yard gain on the first possession of the third quarter. That set up an 8-yard touchdown pass from Lamar Jackson to Zay Flowers to put the Ravens (1-1) ahead 16-6.

Henry finished with 84 yards and a touchdown on 18 carries.

Jackson was 21 of 34 for 247 yards with a touchdown and an interception.

The Raiders capitalized after Robert Spillane intercepted Jackson at the Baltimore 46-yard line with Las Vegas down 16-6 midway through the third quarter. Alexander Mattison capped the Raiders' ensuing 7-play drive with a 1-yard plunge with 2:36 left in the third.

Las Vegas managed 27 yards on 17 carries Sunday.

Henry responded for the Ravens with a three-yard touchdown run early in the fourth quarter to give Baltimore some breathing room at 23-13.

Carlson made a 25-yard field goal before the Raiders pulled even at 23 on Adams' 1-yard touchdown catch from Gardner Minshew with 3:54 left in the game.

The Ravens' next drive stalled, and a poor punt coupled with a penalty situated Las Vegas at the Baltimore 43-yard line with 2:21 to go. Minshew drove the Raiders 23 yards on six plays to set up Carlson's go-ahead kick.

Minshew was 30 of 38 for 276 yards with a touchdown and interception. He was sacked five times.

Defensive end Maxx Crosby had both of Las Vegas' sacks and finished with four tackles for loss.

The game was delayed for about 10 minutes in the second quarter after a member of the NFL operations crew suffered a medical emergency. The staffer was "alert and responsive" as they were taken to a local hospital, according to the Ravens.

Baltimore outside linebacker Kyle Van Noy played despite suffering an orbital bone fracture 10 days ago against Kansas City. He managed two sacks.

Both teams continued to struggle to move the ball in the first half. Carlson and Justin Tucker combined for five field goals and the Ravens led 9-6 at the break.

The Raiders managed 43 yards with four first downs in the first half.