No. 21 Missouri’s top running back Nate Noel will miss this week’s game against No. 15 Alabama with a foot injury, ESPN reported Wednesday.

Officially, Noel is listed as “doubtful” by the Tigers (6-1, 2-1 Southeastern Conference).

Noel is not expected to practice this week and will be re-evaluated after Missouri’s bye week on Nov. 2, per the report.

Noel leads Missouri with 503 yards rushing, good for sixth in the SEC. Senior Marcus Carroll leads the Tigers with six rushing TDs and has 321 yards rushing. Quarterback Brady Cook has contributed four rushing TDs. Noel also has 14 receptions for 45 yards.

Noel was injured in last week’s game vs. Auburn. He sustained the injury in the first half, briefly returned in the second half and finished with six carries for 32 yards.

Alabama (5-2, 2-2) has lost two of its past three games.